IPS1 interacts with TRADD, RIP1 and FADD

Mammalian IPS-1 was shown to interact with death domain (DD)-containing proteins FADD (Fas-associated death domain), RIP-1(receptor-interacting protein)and TRADD (TNFR-associated death domain) to mediate NFkB activation.哺乳动物IPS-1被发现能与包含死亡域（DD）的蛋白质FADD（Fas相关死亡域）、RIP-1（受体相互作用蛋白）和TRADD（TNFR相关死亡域）相互作用，以介导NFkB的激活。