Pre and Post antibiotic epoch: the historical spread of antimicrobial resistance

Genome analysis of pre-antibiotic era (PAE) plasmids from the Murray collection and their modern relatives. This Zenodo archive contains data related to our study on the evolution of PAE plasmids and the origin of antimicrobial resistance vectors: Cazares, A. et al. Pre and Post antibiotic epoch: insights into the historical spread of antimicrobial resistance. (2025). This archive contains the Murray plasmid assemblies and cytoscape files of the networks presented in our study. Files list: Murray_plasmids-Illumina_assemblies-files_list.txt: List of 765 Murray plasmid Illumina assemblies Illumina_assemblies.tar.gz: Sequences of the 765 Murray plasmid Illumina assemblies Murray_plasmids-hybrid_assemblies-files_list.txt: List of 218 Murray plasmid hybrid assemblies hybrid_assemblies.tar.gz: Sequences of the 218 Murray plasmid hybrid assemblies Networks.tar.gz: Compressed directory with the following networks: PAEModern_plasmids_similarity_network-Illumina_assemblies.cys: Murray plasmids (Illumina assemblies) and close relatives similarity network Murray_plasmids_containment_network-Illumina_assemblies.cys: Network of Murray plasmids (Illumina assemblies) containment in Modern-CF plasmids PAEModern_plasmids_similarity_network-hybrid_assemblies.cys: Murray plasmids (hybrid assemblies) and close relatives similarity network Murray_plasmids_containment_network-hybrid_assemblies.cys: Network of Murray plasmids (hybrid assemblies) containment in Modern-CF plasmids Integrated_plasmids_database_similarity_network.cys: Similarity network for the dataset of plasmids collected from the public archive NOTE: Refer to the GitHub repository Murray_plasmids for software and code related to this study.