The functional significance of upregulation miR-34a in combination with albumin-bound paclitaxel nanoparticles in U251 glioblastoma cell line has been evaluated. The MTT assay determined that miR-34a
The ΣFIC was calculated as FIC A + FIC B where the combinations are considered synergistic when the ΣFIC value is <0.5, weakly synergistic when ΣFIC is 0.6 to 1.0, additive when ΣFIC is 1.0 to 2.0 and
Major efforts are underway to identify agents that can potentiate effects of immune checkpoint inhibition. Here, we show that ascorbic acid (AA) treatment caused genome wide demethylation and enhanced
Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1, a BET protein in
