test the activation of beta catenin in APC and CTNNB1 mutated samples (CCA cell lines and patient samples) versus WT Overall design: 3 mutant cell lines (1x CTNNB1, 1x APC, 1x RNF43) versus 2 non-muta
The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of crypt-resident intestinal epithelial stem cells (IESCs). Wnt/Ã-catenin signaling is required for IESC mainten
Gene expression profiling of Pygo2 mutant branchyal arches (BA) and developing heart tubes at 10.5 days post coitum isolation of branchyal arches and developing heart tubes from individual Pygo2 mutan
Up to 41% of hepatocellular carcinomas (HCCs) result from activating mutations in the CTNNB1 gene encoding β-catenin. β-catenin has dual cellular functions as a component of the Wnt signaling pathway
