Effects of GLYN122 on Motor Behavior in R6/2 Mice of Huntington’s Disease

The objective of this study was to investigate the effects of GLYN122 on body weight and motor deficits in transgenic R6/2 mice of Huntington’s disease. Total of 20 female and male R6/2 mice and 10 female and male wild-type littermate control mice (WT) were used in the study. The mice were genotyped and the R6/2 mice were divided into different treatment groups based on their litter and baseline body weight. The treatment with Vehicle or GLYN122 (33 mg/kg; 5 ml/kg, i.p. QD) was started at 4 weeks of age after the baseline behavioral tests. Body weights were measured at 3 weeks of age and twice a week until the end of the study. Motor function testing using rotarod were commenced at 4 weeks (pre-treatment baseline) and continued at 6, 8 and 10 weeks of age, accompanied with grip strength at 4 (pre-treatment baseline), 10 and 12 weeks of age. At the end point of 12 weeks of age the mice were subjected to tissue collection, and the brain samples were used for immunohistochemical analyses. You will find here the full set of the animal research data deposited.