Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig

ChEBI2015-02-17 更新2026-07-21 收录

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-64712 数据链接链接失效反馈

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Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig

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2015-02-17

The Toxoplasma gondii virulence factor ROP16 acts in cis and trans and suppresses T cell responses [BMMC_invitro_stim_24hr]

弓形虫毒力因子ROP16

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The ability of Toxoplasma gondii to inject the rhoptry kinase ROP16 into host cells results in the activation of the transcription factors STAT3 and STAT6, but it is unclear how these events impact in

NIAID Data Ecosystem60

Suppression of antitumor immunity by the oncometabolite 2-hydroxyglutarate. Homo sapiens

肿瘤代谢免疫

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Isocitrate dehydrogenase (IDH) mutations, a hallmark of gliomagenesis, result in the production of the oncometabolite R-2-hydroxyglutarate (R-2-HG) which is thought to promote tumorigenesis via DNA me

NIAID Data Ecosystem40

Potent Suppression of Kv1.3 Potassium Channel and IL-2 Secretion by Diphenyl Phosphine Oxide-1 in Human T Cells

Kv1.3钾通道药理学

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Diphenyl phosphine oxide-1 (DPO-1) is a potent Kv1.5 channel inhibitor that has therapeutic potential for the treatment of atrial fibrillation. Many other Kv1.5 channel blockers also potently inhibit

Figshare2016-01-18 更新20

Structure and Function of a Fungal Adhesin that Binds Heparin and Mimics Thrombospondin-1 by Blocking T Cell Activation and Effector Function

真菌致病性

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Blastomyces adhesin-1 (BAD-1) is a 120-kD surface protein on B. dermatitidis yeast. We show here that BAD-1 contains 41 tandem repeats and that deleting even half of them impairs fungal pathogenicity.

NIAID Data Ecosystem40

Data_Sheet_1_iCa2+ Flux, ROS and IL-10 Determines Cytotoxic, and Suppressor T Cell Functions in Chronic Human Viral Infections.pdf

慢性感染机制

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Exhaustion of CD8+ T cells and increased IL-10 production is well-known in chronic viral infections but mechanisms leading to loss of their cytotoxic capabilities and consequent exhaustion remain uncl

NIAID Data Ecosystem30

Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig

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