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Genome-wide screening reveals the key genes that are responsible for trametinib-induced apoptosis

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NIAID Data Ecosystem2026-05-01 收录
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To explore the geness that are responsible for trametinib-induced apoptosis, we performed Genome-scale CRISPR-Cas9 knockout screening in GSU with 0.015% DMSO or 15 nM trametinib for 14 days. We found that TP53 is critical for executing trametinib-induced apoptosis. Overall design: GeCKO Library screen in GSU with vehicle or tramrtinib for 14 days.

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2023-06-21
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