Supplementary materials for "Unveiling the genetic architecture of primary aldosteronism: a multi-omics investigation into subtype-specific insights"

We conducted a genome-wide Mendelian randomization analysis using adrenal tissue-specific expression quantitative trait loci and hyperaldosteronism genomic data. Replication analysis was performed using a series of independent genome-wide association study datasets. Protein-protein interaction network, pathway enrichment analysis, single-cell RNA-sequencing data, and Bayesian colocalization analysis were employed to validate and prioritize candidate genes.