FRT thyroid cells: 2D monolayers vs. 3D follicles

Transcriptional profiling of the Fischer Rat Thyroid (FRT) cells comparing polarizing cells grown as a confluent two-dimensional monolayer (2D culture system) with cells grown in matrigel where they acquire a three-dimensional follicular structure (3D culture system).The goal was to identify regulators of 3D epithelial thyroid polarization and follicle formation.该数据集针对费希尔大鼠甲状腺（Fischer Rat Thyroid, FRT）细胞开展转录组分析，对比了两类培养条件下的细胞：一类是以汇合二维单层形式培养的极化细胞（二维培养体系），另一类是在基质胶中培养并形成三维滤泡结构的细胞（三维培养体系）。本研究旨在鉴定调控3D上皮甲状腺极化与滤泡形成的调控因子。