Derived data and analysis code for Multiregional transcriptomic and chromatin analyses nominate lineage-specific glial states in human amyotrophic lateral sclerosis

This record contains derived statistical results, machine-readable source tables, analysis scripts, software-environment records, file manifests, and checksums supporting a multiregional study-calibrated analysis of glial transcriptomic and chromatin states in human amyotrophic lateral sclerosis. The analyses integrate donor-level pseudobulk RNA profiles from six spinal and cortical contexts across four accession-defined studies, explicitly account for shared donors, and include calibrated PXDN meta-analysis, harmonized gene-set analyses, oligodendroglial sterol sensitivities, fragment-based FRiP analyses, CTCF motif analyses, and RNA–ATAC integration. Primary sequencing data are not redistributed and remain available from the source repositories under GSE287257, GSE330130, GSE219280, GSE290359, GSE271156, and the reference/model accessions documented in the included inventory.