Supplementary Material

<b>Supplementary Table 1.</b> The transition pattern of the 7 common uremic indicators between case and control periods before hemodialysis initiation (N = 1,079). “No” means the indicator does not reach the predefined cutoff values shown on the first column, whereas “Yes” means the opposite. The order of these indicators follows the frequency of “no-to-yes” from high to low. <b>Supplementary Table 2. </b>Biochemical characteristics in control and case periods (N = 1,079) <b>Supplementary Table 3. </b>Distribution of 30-day and daily doses of furosemide in control and case periods and based on the three dialysis timing groups. <b>Supplementary Figure 1.</b> Flow diagram of patient selection. <b>Supplementary Figure 2.</b> Case-crossover study design and timing of exposure measurements including uremic indicators and medications in relation to hemodialysis initiation.