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Scalable, Divergent Synthesis of Meroterpenoids via “Borono-sclareolide”

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NIAID Data Ecosystem2026-03-07 收录
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A scalable, divergent synthesis of bioactive meroterpenoids has been developed. A key component of this work is the invention of “borono-sclareolide”, a terpenyl radical precursor that enables gram-scale preparation of (+)-chromazonarol. Subsequent synthetic operations on this key intermediate permit rapid access to a variety of related meroterpenoids, many of which possess important biological activity.

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2016-02-20
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