Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner

This study used a mouse model of diet-induced obesity with fetal overgrowth to investigate molecular changes in the placentas of obese dams. Obese and control dams were euthanized on embryonic day 18.5 to collect placental samples for RNA sequencing. Overall design: RNA-Seq was carried out to compare gene expression in the placentas of obese (n=10) and control (n=10) dams. Obese and control groups each had an equal number of male and female fetuses.