Genome-wide analyses of long non-coding RNA expression profiles and functional network analysis in esophageal squamous cell carcinoma

The aim of this study was tantamount to screen and analyze the differential expression profiles of lncRNAs in ESCC, as well as to analyze the differentially expressed lncRNAs function and related acting molecules to further understand the role of lncRNAs in the occurrence and development of ESCC. Genome-wide expression of lncRNAs and mRNAs was determined in 5 pairs of ESCC and matched normal esophageal tissue using microarray. 6 lncRNAs were detected by qRT-PCR to verify the results of the microarray, and the clinicopathological parameters were analyzed in 53 ESCC patients.