Gene expression of patient derived xenograft glioblastoma treated with DMSO control or Panobinostat.

Panobinostat is a non-selective histone deactylase inhibitor which has been approved by FDA for treatment of mutiple myeloma. Whether and how the drug works on glioblastoma remains unclear. Here we treated mice implanted with patient derived xenograft glioblastoma G43 with DMSO or Panobinostat and harvest the tumors for microarray analysis for gene expression results. Tumors were collected from DMSO or Panobinostat treated mice. Total RNA were collected and microarray were performed to compare the differences of gene expression.