Genome-wide significant SNPs from the joint meta-analysis (JMA) of SNP and SNP-by-smoking (ever-smoking or pack-years) interaction in relation to pulmonary function.

After removing SNPs with known associations with FEV1/FVC or FEV1, three novel loci with genome-wide significant SNPs (standard threshold of P−8) remained from the JMA testing in the current study. The most significant SNP from each locus is shown.FEV1, forced expiratory volume in the first second; FVC, forced vital capacity; JMA, joint meta-analysis; SE, standard error ; SNP, single nucleotide polymorphism.1Weighted average coded allele frequency across the 19 studies. The coded allele refers to the effect allele.2βSNP, per allele change in the FEV1/FVC standardized residual due to the SNP main association.3βINT, per allele change in the FEV1/FVC standardized residual due to the interaction between SNP and smoking.