NEIL2

This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]

该基因编码Fpg/Nei家族DNA糖苷酶的成员。此类糖苷酶通过切割氧化性损伤的碱基并利用其无碱基位点裂解活性引入DNA链断裂，从而启动碱基切除修复的第一步。该酶主要与转录期间的DNA修复相关联，并优先作用于由胞嘧啶衍生的损伤，尤其是5-羟基尿嘧啶和5-羟基胞嘧啶。该酶含有N端催化结构域、铰链区域和C端DNA结合结构域，其中包含二级结构-转角-二级结构模体和锌指模体。该酶作为多蛋白DNA修复复合体的一部分，与X射线交叉互补因子1支架蛋白相互作用。已鉴定出该基因的假基因。[由RefSeq提供，2017年3月]