Protein-protein interactions of HCMV virion proteins that have either been previously reported or suggested, and were positive in our YTH and co-IP analysis.

Interactions marked by an asterisk represent reciprocal interactions. “+” represents positive interactions identified by co-IP experiments in human cells (co-IP). The ORFs in which deletion results in no viral growth, wildtype-like growth, and significant growth defect in foreskin fibroblasts are marked as “E” (essential), “NE” (non-essential), and “D” (defect) [7].