RNA-Seq of the posterior subcutaneous fat of mice after 3-week treadmill training versus sedentary control

This study investigates the effects of exercise and genetic predisposition on the transcriptomic profile of the posterior subcutaneous fat of long-term selected marathon (DUhTP) and non-inbred (DUC) mice. In the exercise group, mice underwent treadmill training for three weeks. For the sedentary control group, mice were kept under minimal physical activities. For the 3-week training program, the mice were running five days per week (Monday to Friday) starting at age of 49 days after birth (Walz et. al. 2021). All mice used in this experiment were male and sacrificed at day 70 of life for tissue sampling.本研究探讨了运动与遗传易感性对长期选育马拉松小鼠（DUhTP）及非近交小鼠（DUC）的皮下后部脂肪转录组谱的影响。其中，运动组小鼠接受为期三周的跑台训练；久坐对照组小鼠则维持极低运动量。本次三周训练方案为：自小鼠出生后49日龄起，每周训练五天（周一至周五），相关实验设计参考Walz等人2021年的研究。本实验所用小鼠均为雄性，于出生后70日龄处死以采集组织样本。