Heldt2002_OrthostaticStress_heart

This a model from the article:
Computational modeling of cardiovascular response to orthostatic stress.

Heldt T, Shim EB, Kamm RD, Mark RG. J Appl Physiol
2002 Mar;92(3):1239-54 11842064
,
Abstract:

The objective of this study is to develop a model of the cardiovascular system
capable of simulating the short-term (< or = 5 min) transient and steady-state
hemodynamic responses to head-up tilt and lower body negative pressure. The
model consists of a closed-loop lumped-parameter representation of the
circulation connected to set-point models of the arterial and cardiopulmonary
baroreflexes. Model parameters are largely based on literature values. Model
verification was performed by comparing the simulation output under baseline
conditions and at different levels of orthostatic stress to sets of
population-averaged hemodynamic data reported in the literature. On the basis of
experimental evidence, we adjusted some model parameters to simulate
experimental data. Orthostatic stress simulations are not statistically
different from experimental data (two-sided test of significance with Bonferroni
adjustment for multiple comparisons). Transient response characteristics of
heart rate to tilt also compare well with reported data. A case study is
presented on how the model is intended to be used in the future to investigate
the effects of post-spaceflight orthostatic intolerance.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Heldt T, Shim EB, Kamm RD, Mark RG. (2002) - version=1.0

The original CellML model was created by:
Catherine Lloyd

[e-mail]
The University of Auckland
This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication
for more information.
In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..

To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.