eQTL GWAS association data for ACE2 and TMPRSS2 in lung tissue from GTEx

GTEx genetic association estimates were obtained in 515 individuals of predominantly European (85%) ancestry. Whole genome sequencing was performed by the Broad Institute’s Genomics Platform and only common variants (minor allele frequency &gt; 0.05) were retained. Genome-wide eQTL analysis was performed for the expression of /ACE2/ and /TMPRSS2/ in primary tissue samples taken from the lung. Genetic associations with imputed variants across the autosomal chromosomes were adjusted for five principal components from the genotype data, 60 probabilistic estimation of expression residuals factors, sequencing platform (Illumina HiSeq 2000 or HiSeq X), sequencing protocol (polymerase chain reaction-based or free), and sex. For each gene, expression values between samples were normalized using the trimmed means of M-values method in EdgeR. Expression values were normalized across samples using an inverse normal transformation. <br>