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Assessing recombination between self-amplifying mRNA vaccines and wild-type alphaviruses in vitro and in vivo

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NIAID Data Ecosystem2026-05-01 收录
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GETV and SAM vaccine were co-injected subcutaneously into the hind feet of 6-10 week old female IFNAR-/-, Rag-/-, and C57BL/6J mice. Feet were harvested at various time points, and had RNA sequenced by bulk RNA-Seq. RNA-Seq data were interrogated to determine if recombination between the GETV genome and the SAM replicon could be detected.

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2023-07-09
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