Synthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling

An asymmetric Ni-catalyzed
reductive cross-coupling has been developed
to prepare enantio­enriched allylic silanes. This enantio­selective
reductive alkenylation proceeds under mild conditions and exhibits
good functional group tolerance. The chiral allylic silanes prepared
here undergo a variety of stereo­specific transformations, including
intramolecular Hosomi–Sakurai reactions, to set vicinal stereogenic
centers with excellent transfer of chirality.