Crystal structure of human PKMYT1 protein kinase domain with Naphthyridinone Inhibitor compound 40

Crystal structure of human PKMYT1 protein kinase domain with Naphthyridinone Inhibitor compound 40 Descriptor: 3-azanyl-4-(7-fluoranyl-2H-indazol-4-yl)-8-methoxy-1H-1,5-naphthyridin-2-one, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, SULFATE ION Authors: Xu, Z.H, Chen, S. Deposit date: 2025-01-10 Release date: 2025-04-16 Last modified: 2025-05-07 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Discovery of Naphthyridinone Derivatives as Selective and Potent PKMYT1 Inhibitors with Antitumor Efficacy. J.Med.Chem., 68, 2025