Transcriptional and epigenetic control of thymic regulatory T cell development
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https://www.ncbi.nlm.nih.gov/sra/DRP003376
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资源简介：
Regulatory T (Treg) cells, which specifically express the transcription factor Foxp3, are actively engaged in life-long suppression of potentially hazardous self-reactive T cells to prevent autoimmune disease. The majority of them develop in the thymus as a functionally distinct and mature T-cell subpopulation, with their Foxp3 expression stabilized mainly by Treg-specific DNA demethylation of the Foxp3 enhancer region CNS2. In this study, we characterized the molecular mechanisms underlying thymic Treg cell development.
创建时间：
2020-06-18
