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Genome-wide Analysis Reveals Mecp2-dependent Regulation of MicroRNAs in a Mouse Model of Rett Syndrome (mm8 tiling array)

ChEBI2010-09-30 更新2026-07-21 收录

发育疾病分子机制

MicroRNA全基因组调控

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-24285 数据链接链接失效反馈

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Genome-wide Analysis Reveals Mecp2-dependent Regulation of MicroRNAs in a Mouse Model of Rett Syndrome (mm8 tiling array)

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创建时间：

2010-09-30

MAPK信号通路调控

发育疾病分子机制

Sotos syndrome (SoS) is characterized by tall stature, characteristic craniofacial features and mental retardation. It is caused by haploinsufficiency of the NSD1 gene. In this study, our objective wa

NIAID Data Ecosystem80

The RNA-binding protein Sfpq regulates long neuronal genes in transcriptional elongation [RNA-seq]. Mus musculus

神经元转录调控

发育疾病分子机制

Mammalian neurons express extra-long pre-mRNAs which are vulnerable to misregualtion of transcriptional elongation or processing but their regulation is still largely unknown. Here we found that RNA-b

NIAID Data Ecosystem70

Additional file 5: Table S5. of Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures

发育疾病分子机制

基因表达通路

Selected over-represented KEGG pathways with core differentially expressed genes in Fmr1KO that made a pathway significant. (XLSX 11 kb)

Figshare2016-12-15 更新40

Additional file 4: of RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome

发育疾病分子机制

CNS细胞类型特异性组学

CNS cell type-specific genes from Zhang et al.’s study compared to the Sharma et al. study. Significant DE genes (DEG) identified as cell type-specific from the Zhang et al. study [69] were compared t

Figshare2017-10-25 更新70

Developmental dynamics of the postsynaptic proteome to understand synaptic maturation and dysmaturation

突触蛋白质组学

发育疾病分子机制

The postsynaptic density (PSD) is a protein condensate composed of ~1,000 proteins beneath the postsynaptic membrane of excitatory synapses. The number, shape, and plasticity of synapses are altered d

NIAID Data Ecosystem50

Genome-wide Analysis Reveals Mecp2-dependent Regulation of MicroRNAs in a Mouse Model of Rett Syndrome (mm8 tiling array)

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