Transcriptional profiling of CD1 mouse liver after 28 days and 90 days of daily administration of Phenobarbital in vivo. Mus musculus

To further our investigations for early biomarkers of non-genotoxic carcinogenesis, groups of mice were treated by gavage with a prototypic non-genotoxic carcinogen: Phenobarbital (PB, CAS: 57-30-7), for a period of 28 and 90d and liver tissue harvested for expression profiling. Control groups were treated with appropriate vehicle (0.5% Methylcellulose). Overall design: Group size was 5 mice (mus musculus, CD1, randomly assigned); all procedures were performed by experienced personnel.