Assay Harmonization Study To Measure Immune Response to SARS-CoV-2 Infection and Vaccines: a Serology Methods Study

To evaluate and compare the reliability, sensitivity, specificity, and reproducibility of a set of widely used commercial and in-house serology assays. To demonstrate that binding immunoassays may serve as a practical alternative for the serological study of large sample sets in lieu of expensive, complex, and less reproducible neutralization assays. To analyze the feasibility of using the WHO IS as a global harmonization tool to facilitate comparison of results between assays.