The contribution of RNA oxidation to acute kidney injury: evidence from ISG20-mediated oxidized RNA degradation

RNA is more vulnerable to oxidation than other cellular components, which is linked to a range of diseases and pathological conditions, such as AKI. To identify the contribution of RNA oxidation to AKI, the mechanisms of how cells handle oxidized RNA should be elucidated. By RNA sequencing analysis in ischemia/reperfusion-induced AKI, we observed the significant changes of genes important in degradingting oxidative RNA. The gene expression of 3 samples from a 24 h renal ischemia/reperfusion-induced AKI was compared to 3 sham samples by RNA sequencing.