MTAG and gSEM common factor summary statistics for 5 psychiatric disorders using PGC studies

This upload contains (A) summary statistics from MTAG meta-analysis and (B) common factor GWAS contained from genomicSEM on GWAS on 5 psychiatric disorders previously published by the Psychiatric Genomics Consortium, removing from each of the 5 original GWAS the individuals from the iPSYCH dataset. The input datasets are:
Attention deficit hyperactive disorder (ADHD): Demontis et al., Nat Gen 2019 [PMID: 30478444] Ncases = 20183 , Ncontrols = 35191, Ntotal = 55374Autism spectrum disorder (AUT): Grove et al., Nat Gen 2019 [PMID: 30804558]Ncases = 18382, Ncontrols = 2769, Ntotal = 46351Bipolar disorder (BPD): Mullins et al., Nat Gen 2021 [PMID: 34002096] Ncases = 41919, Ncontrols = 371549, Ntotal = 413466Major depressive disorder (MDD): Howard et al., Nat Comms 2019 [PMID: 30718901]Ncases = 170756, Ncontrols = 329443, Ntotal = 500199Schizophrenia (SCZ): Trubetsky et al., Nature 2022 [PMID: 35396580]Ncases = 50948, Ncontrols = 21151, Ntotal =72099For the MTAG summary statistics, each file contain the following columns:
CHROM: chromosomePOS: position of SNP on chromosome ID: rsID of SNP A1: Effect alleleA2: Other alleleA1FREQ: Frequency of effect alleleN: Sample sizeZ: Z score from original GWAS summary statistics MTAG_beta: MTAG effect size MTAG_se: Standard error for MTAG effect size MTAG_z: MTAG Z score MTAG_pval: MTAG P value The gSEM common factor GWAS summary statistics contains the following columns:
CHROM: chromosomePOS: position of SNP on chromosomeID: rsID of SNPA1: Effect allele A2: Other alleleEstimate: effect size of SNP on common factorSE: standard error of effect size Z: Z scoreP: P value of association between common factor and SNP genotype Qest: Measure of heterogeneity between SNP effect size on the 5 inputs into the common factor model Qest_P: P value of heterogeneity of SNP effect size