Results of parameter exchange analysis.

Table indicates the direction in which the exposure (AUC) of MTR changes after IT instillation, upon exchanging the indicated parameter values between airway and alveoli. A plus indicates an increase, while a minus indicates a decrease in AUC relative to the baseline lung model parameters. One plus or minus sign corresponds to a 1.1 to 1.5 fold change in AUC; two plus or minus signs to a 1.5 to 2 fold change; and three plus or minus signs to a >5 fold change. For clearance, the parameter value was increased 10-fold.