single cell-RNA sequencing of the effects of exercise on db/db mice pancreas

The prevalence and mortality rates of type 2 diabetes mellitus (T2DM) continue to increase, imposing a significant burden on individuals and nations worldwide. The pancreas plays an important role in T2DM development, while exercise is a crucial nonpharmacological treatment. Although the pancreas comprises various cell types, current studies on the effects of exercise on diabetes have mainly focused on the beta cells. In this project, we aimed to enhance our understanding of the effects of exercise on other pancreatic cell types. This was aimed at facilitating the comprehensive analysis of the processes and principles by which exercise protects and enhances pancreatic function.