Investigation of radiosensitivity gene signatures in cancer cell lines. Homo sapiens

Commercially available cell lines derived from Head and Neck Squamous cell carcinoma (HNSCC) were cultured and baseline gene expression values were assayed. We used microarrays to detail the global programme of gene expression underlying differences in radiosensitivity as measured by surviving fraction at 2Gy (SF2) Overall design: HNSCC Cell lines (n=11) were cultured in standard conditions. RNA was extracted at subconfluence.