Expression data for tumor and normal tissue samples from deceased sepsis and non-sepsis colorectal cancer patients

The mortality risk from cancer-associated sepsis is differentially affected by individual cancer sites and host responses to sepsis are heterogenous. Native Hawaiians have a 2-fold higher mortality risk from cancer-associated sepsis than Whites and also higher mortality risk from colorectal cancer (CRC). We investigated this disparity by examining ethnic variation in the transcriptome of patients with CRC-associated sepsis and its relation to survival and genetic diversity. We conducted transcriptomic profiling of CRC tumors and adjacent non-tumor tissue obtained from adult patients of Native Hawaiian and Japanese ethnicity who died from cancer-associated sepsis. We examined differential gene expression in relation to patient survival and sepsis disease etiology. FFPE tumor and adjacent normal tissue was obtained from 30 Hawaiian and Japanese CRC patients. 15 patients who died of sepsis were age and ethnicity matched to patients with non-sepsis cause of death.