Transcriptomic profiling of bone marrow stromal cell subsets during chronic viral infection with LCMV. Transcriptomic profiling of bone marrow stromal cell subsets during chronic viral infection with LCMV

RNA sequencing of two stromal cell subsets of the bone marrow, namely CXCL12-abundant reticular cells (CARc) and sinusoidal endothelial cells (SECs) isolated from untreated mice (day 0) and mice infected with Lymphocytic Choriomeningitis Virus cl-13, 56 days after infection (day 56) Overall design: RNA-sequencing of two FACS-sorted mouse bone marrow stromal cells based on phenotypic marker expression from uninfected control (day 0) and LCMV-cl13 infected mice (56 day post infection-day 56). Cell subsets were sorted according to previously defined phenotypic signatres. CARc; CD45-Ter119-Cd31-CD140b+Sca-1- . SECs; CD45-Ter119-CD31+Sca-1+CD105hi