The mevalonate pathway is essential in eukaryotes and responsible for a diversity of fundamental synthetic activities. 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the rate-limiting enzym

NIAID Data Ecosystem30

Crystal structure of SCP2 thiolase from Leishmania mexicana: The C123S mutant.

寄生虫酶功能

热带病病原体蛋白功能

Crystal structure of SCP2 thiolase from Leishmania mexicana: The C123S mutant. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-KETOACYL-COA THIOLASE-LIKE PROTEIN, CHLORIDE ION, ... Authors: Harijan, R.K,

Protein Data Bank Japan2023-12-20 更新20

Crystal structure of Schistosoma mansoni HDAC8 in complex with a 4-chlorophenyl-spiroindoline capped hydroxamate-based inhibitor, bound to a novel site

寄生虫酶功能

靶向药物设计

Crystal structure of Schistosoma mansoni HDAC8 in complex with a 4-chlorophenyl-spiroindoline capped hydroxamate-based inhibitor, bound to a novel site Descriptor: 5-[[(2S)-2-(4-chlorophenyl)-1'-methy

Protein Data Bank Japan2024-01-31 更新30

Discovery of novel antischistosomal scaffolds from the open access Pandemic Response Box

抗血吸虫病药物

分子筛选

Treatment and control of schistosomiasis rely on a single drug, praziquantel. New orally active antischistosomals featuring novel molecular scaffolds are urgently needed to prevent the emergence of re

Figshare2021-10-19 更新20

Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 1,4-Bis(2-hydroxyethyl)piperazine

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