Human Placental Transcriptome and fetal sex differences in Spontaneous Preterm Birth. Human Placental Transcriptome and fetal sex differences in Spontaneous Preterm Birth

Placental insufficiency is implicated in spontaneous preterm birth (SPTB). We performed RNA-seq study in male and female placentas from women (African American, self-identified) with SPTB (< 36 weeks gestation) compared to normal pregnancies (≥ 38 weeks gestation) to assess the alterations in gene expression profiles. Overall design: Examination of transcriptomes in 4 experimental conditions (SPTB males, SPTB females, Term males, and Term females)