CircRNAs in BALF exosomes and plasma as diagnostic biomarkers in patients with acute respiratory distress syndrome caused by severe pneumonia

To screen and validate abnormally expressed circRNAs in exosomes from BALF of patients with ARDS caused by severe pneumonia, and then evaluate the diagnostic values of these circRNA for ARDS CircRNAs expression profile was obtained by microarray analysis in BALF exosomes of discovery cohort. Competitive endogenous RNA network construction and functional enrichment analysis were performed.