Highly Selective Intramolecular Carbene Insertion into Primary C–H Bond of α-Diazoacetamides Mediated by a (<i>p</i>-Cymene)ruthenium(II) Carboxylate Complex
收藏NIAID Data Ecosystem2026-03-09 收录
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资源简介：
Complex [(p-cymene)Ru(η1-O2CCF3)2(OH2)] mediated transformation of α-diazoacetamides ArCH2N(C(CH3)3)C(O)CHN2 to result in carbene insertion into the primary C–H bond exclusively, with the γ-lactam products being isolated in up to 98% yield. This unexpected reaction is striking in view of the presence of usually more reactive sites such as secondary C–H bonds in the substrates. DFT calculations based on proposed Ru-carbene species provide insight into this unique selectivity.
创建时间：
2016-02-20
