Establishment and characterization of patient-derived xenograft from leptomeningeal spread of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion.. Establishment and characterization of patient-derived xenograft from leptomeningeal spread of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion.

To establish and to characterize patient derived preclinical model of rare pediatric glioma, anaplastic pleomorphic xanthoastrocytoma. The model was derived from tumor found at leptomeningeal spread site. we perform multi omics analysis including in this file is RNA seq to asses molecular fidelity of the patient derived model ( xenograft and xenoline) compared to original tumor from patient. Overall design: Comparative gene expression profiling analysis of RNA-seq data for xenograft passage 1 (PDX1281) and 2 (PDX1282), xenoline (X128), normal human astrocyte and patient tumor (Pttumor)