Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology and treatment

The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase (IDH)1-mutated tumor entities affirmed the role of metabolism in cancer. Yet, large databases with gene expression data and tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present an unprecedented and valuable resource for tissue gene expression in diffuse glioma and their modulations by IDH1 mutation, histology and tumor treatments in 88 tissue samples (32 astrocytoma, 23 oligodendroglioma, 33 glioblastoma) from 71 diffuse glioma patients (17 patients with two resection time points), investigated by RNA sequencing (and NMR-based metabolomics).