Innate immunity is a non-specific host immune response against pathogen invasion. It exists widely in most of cells and is considered as the first line of defense against pathogen infection. Upon viru

NIAID Data Ecosystem40

Ebola Virus Selectively Inhibits Responses to Interferons, but Not to Interleukin-1β, in Endothelial Cells

病毒免疫逃逸机制

干扰素信号通路

Ebola virus infection is highly lethal and leads to severe immunosuppression. In this study, we demonstrate that infection of human umbilical vein endothelial cells (HUVECs) with Ebola virus Zaire (EZ

PubMed Central10

Introns encode dsRNAs undetected by RIG-I/MDA5/interferons and sensed via RNase L. Introns encode dsRNAs undetected by RIG-I/MDA5/interferons and sensed via RNase L

干扰素信号通路

RNaseL功能研究

RNA-seq of cytoplasmic RNAs in RNase L KO A549 cells shows increased intron load compared to WT cells. Overall design: WT and RNase L KO A549 cells treated with lipofectamine for 12h, cytoplasmic frac

NIAID Data Ecosystem70

Comparison of the effects of early pregnancy with human interferon, alpha 2 (IFNA2) on gene expression in bovine endometrium

妊娠识别机制

干扰素信号通路

Interferon tau (IFNT), a Type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal, produced by the ruminant conceptus. To elucidate specific effects of bovine IFNT and of other con

NIAID Data Ecosystem30

Ku70 Is a Novel Cytosolic DNA Sensor that Induces Type-III Rather than Type-I IFN

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