The nucleoporin Nup170p is required for subtelomeric chromatin organization and gene silencing. [MNase-Seq]

Transcriptionally silent heterochromatin preferentially localizes at the nuclear periphery, but, despite this, certain budding yeast genes relocate to the nuclear periphery following gene activation, implicating the nuclear envelope in both transcriptional activation and silencing转录沉默的异染色质（heterochromatin）优先定位于核外周（nuclear periphery），但即便如此，部分出芽酵母的基因在激活后会迁移至核外周，这提示核被膜（nuclear envelope）同时参与转录激活与转录沉默过程。