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PDGFRβ signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis

NIAID Data Ecosystem2026-05-01 收录

硬纤维瘤分子机制

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数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE239409 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-11-02

透明细胞癌靶向治疗

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Clear cell ovarian cancer is an epithelial ovarian cancer histotype that is less responsive to chemotherapy and carries poorer prognosis than serous and endometrioid histotypes. Despite this, patients

NIAID Data Ecosystem50

The TCL1A Oncoprotein Interacts Directly with the NF-κB Inhibitor IκB

代谢物-蛋白相互作用

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The T cell leukaemia/lymphoma 1A (TCL1A) oncoprotein plays key roles in several B and T cell malignancies. Lacking enzymatic activity, TCL1A's transforming action was linked to its capacity to co-acti

NIAID Data Ecosystem30

YAP/TAZ drives cell proliferation and tumour growth via a polyamine-eIF5A hypusination-LSD1 axis

肿瘤信号通路

表观遗传调控

Here using mouse genetic models and human cancer cells, we show that YAP/TAZ reprogram polyamine metabolism to promote cell proliferation and tumor growth. Mechanistically, YAP/TAZ increases polyamine

NIAID Data Ecosystem20

TNFR2 HnRNPK-YAP Signaling Axis Promotes Primary Liver Cancer Development in Hepatic Progenitor Cells. TNFR2 HnRNPK-YAP Signaling Axis Promotes Primary Liver Cancer Development in Hepatic Progenitor Cells

原发性肝癌单细胞转录组

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We performed single-cell RNA sequencing (scRNA-seq) analysis using clinical samples of PLC patients. We first generated scRNA-seq profiles of freshly isolated PLC from patients with 10x Genomics. A to

NIAID Data Ecosystem40

STAT5 occupancy profiling in GSCs (CUT&Tag)

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表观基因组学

We investigated the STAT5 genomic binding regulated by EGFR signaling in GSCs CUT&Tag using antibody against STAT5 in GSC456 cells untreated (UT) or treated with erlotinib

NIAID Data Ecosystem20

PDGFRβ signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis

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