Amino acid and other sequence changes in 17syn+-derived viruses.

The genomes of 17syn+, 17ΔN/H, 17-37, m2kb-S, Δ1773, 17ΔPstR, 17dmiR-H1/H6 (dH1/H6), and 17REdmiR-H1/H6 (RE) used in the study were sequenced. Amino acid sequence changes found in each virus, the types of differences (SNP leading to substitution or indel leading to frameshift) and their locations in the 17syn+ genome (GenBank accession JN555585.1), are specified in the first spreadsheet. Substitution occurrence (%) is given where the lighter shading reflects low occurrence and the darker shading high occurrence. All SNPs and indels in non-coding and coding regions are listed in the spreadsheets following an overview of the datasets. Their locations in the 17syn+ genome are indicated (GenBank accession JN555585.1 genome location column). In addition, the locations in the reference genome used in the alignment, which is trimmed of all but the 100 nt of TRL and TRS adjacent to UL and US, respectively, are given (reference location column). The changes are classified as minor, major, or complete, depending on the proportion of genomes affected. (XLSX)