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Crystal structure of dihydrofolate reductase (DHFR) from the filarial nematode W. bancrofti in complex with NADPH and methotrexate (MTX)

NIAID Data Ecosystem2026-05-02 收录

抗寄生虫药物靶点结构

基于结构的药物设计

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Crystal structure of dihydrofolate reductase (DHFR) from the filarial nematode W. bancrofti in complex with NADPH and methotrexate (MTX)

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创建时间：

2025-09-03

抑制剂结构

基于结构的药物设计

Crystal structure of human serine threonine kinase-10 bound to SU11274 Descriptor: (3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-1H-PYRROL-2-YL}METHYLENE)-N-METHYL-2-OX

Protein Data Bank Japan2024-11-20 更新50

Crystal structure of NAD kinase 1 from Listeria monocytogenes in complexe with an inhibitor

抗菌药物靶点

基于结构的药物设计

Crystal structure of NAD kinase 1 from Listeria monocytogenes in complexe with an inhibitor Descriptor: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(

Protein Data Bank Japan2024-05-15 更新30

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with an inhibitor 617

蛋白质结构解析

基于结构的药物设计

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with an inhibitor 617 Descriptor: (2~{S})-2-[[(2~{S})-6-[[(2~{S})-3-naphthalen-2-yl-2-[[4-[[2-[(11~{Z})-4,7,10-tris(2-hydroxy-

Protein Data Bank Japan2026-03-04 更新10

Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators

基于结构的药物设计

ATX-LPA信号通路靶向治疗

Autotaxin (ATX) facilitates the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA), a bioactive phospholipid, which facilitates a diverse range of cellular effects in multiple tissue

NIAID Data Ecosystem40

humanized rat COMT in complex with 5,6-bis(4-fluorophenyl)-8-hydroxy-3H-quinazolin-4-one

蛋白质-配体复合物结构

基于结构的药物设计

humanized rat COMT in complex with 5,6-bis(4-fluorophenyl)-8-hydroxy-3H-quinazolin-4-one Descriptor: (4S,5S)-1,2-DITHIANE-4,5-DIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 5,6-bis(4-fluorophenyl)-8

Protein Data Bank Japan2024-04-03 更新20

Crystal structure of dihydrofolate reductase (DHFR) from the filarial nematode W. bancrofti in complex with NADPH and methotrexate (MTX)

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