The role of human endogenous retrovirus (HERV)-K env in THP-1 monocytic cell differentiation

We generated HERV-K env gene KO in THP-1, a monocytic cell can be differentiated into macrophage, to investigate the role of HERV-K env in immune regulation. As the results, cell migration and invasion were significantly increased in HERV-K env KO THP-1 cells compared to MOCK, and these results were completely opposite to those of cancer cells Overall design: We generated HERV-K env gene KO in THP-1,