Gene expression profile during cardiac stress induced by transverse aortic constriction (TAC) and myocardial infarction (MI) with or without BET protein inhibitor JQ1 in mouse hearts. Mus musculus

Purpose: to reveal cardiac stress-inducible genes that are attnuated by BET inhibition Overall design: Method: Adult C57Bl/6 mice (male, 10 wks) were subjected to sham surgery and received vehicle injection for 6 weeks starting post-op week 4. Method: Adult C57Bl/6 mice (male, 10 wks) were subjected to TAC surgery with a 27 gauge needle. Starting at the beginning of post-op week 4, JQ1 at 50 mg/kg/d was adminstrated via I.P. injections and continue for another 6 weeks. Method: Adult C57Bl/6 mice (male, 10 wks) were subjected to Permanent Ligation of the Left Anterior Descending Coronary Artery. Beginning from post-op day 6, JQ1 at 25 mg/kg/d or vehcle was given via I.P. for 6 days and then increased to 50 mg/kg/d for additional 16 days.