Cx3cr1 deficiency reduces collagen induced arthritis in lupus-prone mice

NIAID Data Ecosystem2026-05-10 收录

自身免疫性关节炎

基因-免疫互作机制

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https://www.ncbi.nlm.nih.gov/sra/SRP631771 数据链接链接失效反馈

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资源简介：

Cx3cr1 deficiency redirected neutrophil trafficking and reduced collagen induced arthritis in lupus-prone MRL/lpr mice in a possibly gut microbiota-dependent manner.

创建时间：

2026-02-20

Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

肠道菌群免疫互作

自身免疫性关节炎

The aim of this study was to investigate the role of IL-1 receptor signalling and the involvement of Toll-like receptor (TLR) 2 and TLR4 in defining the intestinal microbiota and the associated mucosa

NIAID Data Ecosystem80

Neutrophils Are Essential As A Source Of Il-17 In The Effector Phase Of Arthritis

自身免疫性关节炎

中性粒细胞免疫

Objective Th17 has been shown to have a pivotal role in the development of arthritis. However, the role of IL-17 in the T cell-independent effector phase has not fully been examined. We investigated w

NIAID Data Ecosystem60

Non-classical CD4+CD49b+ regulatory T cells as a better alternative to conventional CD4+CD25+ T cells to dampen arthritis severity. Mus musculus

调节性T细胞治疗

自身免疫性关节炎

Regulatory T (Treg) cells actively control pathological immune responses and immunotherapeutic strategies triggering an increase in the number and/or the function of endogenous Treg cells emerge as a

NIAID Data Ecosystem30

Data_Sheet_1_Deficiency of STING Promotes Collagen-Specific Antibody Production and B Cell Survival in Collagen-Induced Arthritis.docx

自身免疫性关节炎

细胞功能调控

The levels of interferon-alpha are high in the serum and synovial fluid of rheumatoid arthritis (RA) patients. Activation of the stimulator of type I interferon genes (STING) mediates the productions

NIAID Data Ecosystem60

AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis

自身免疫性关节炎

AIM2炎症小体

Mice lacking DNase II display a polyarthritis-like disease phenotype that is driven by translocation of self-DNA into the cytoplasm of phagocytic cells, where it is sensed by pattern recognition recep

NIAID Data Ecosystem50

Cx3cr1 deficiency reduces collagen induced arthritis in lupus-prone mice

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