Biomimetic Models of the Active Site of the Metalloenzyme Nitrile Hydratase

In the interest of a wider dissemination of the knowledge contained therein, the author's <strong>PhD Thesis</strong>, entitled <strong><em>"Biomimetic Models of the Active Site of the Metalloenzyme Nitrile Hydratase"</em></strong> (University of Washington, Seattle, <strong>2001</strong>), is reproduced here. To illustrate the evolution of knowledge, the author's Precandidacy (1998) and General Exam (1999) papers and a poster (2000) are included. All of the experimental results contained within this PhD thesis have by now been reported in journal articles. However, <strong><em>this thesis provided room for a much more detailed presentation of the experimental results and their discussion and analysis.</em></strong> {FeNO}6 model compound [chapter 2]: <em>Journal of the American Chemical Society</em> <strong>1998</strong>, <em>120</em>, 10996-10997 http://pubs.acs.org/doi/abs/10.1021/ja981117e Oxygenated Co(III)-thiolate complexes [pages 16-17 &amp; 113-116]: <em>Journal of the American Chemical Society</em> <strong>2000</strong>, <em>122</em>, 8299-8300 http://pubs.acs.org/doi/abs/10.1021/ja0017561 Improved synthesis of tetramethylammonium azide: <em>Croatica Chemica Acta</em> <strong>2001</strong>, <em>74</em>, 415-418 http://public.carnet.hr/ccacaa/CCA-PDF/cca2001/v74-n2/cca_74_2001_415-418_Schweitzer.pdf Reactivity as a function of an Et,Pr or Pr,Pr ligand backbone to model the entatic state of an enzymatic active site [chapter 3]: <em>Inorganic Chemistry</em> <strong>2002</strong>, <em>41</em>, 3128-3136 http://pubs.acs.org/doi/abs/10.1021/ic0109187 Fe(III) complexes of an (Namide)2(Sthiolate)2 ligand [chapter 4]: <em>Inorganic Chemistry</em> <strong>2008</strong>, <em>47</em>, 11228-11236 http://pubs.acs.org/doi/abs/10.1021/ic801704n